P03-15 - Evaluation of Sedative Effects of Antipsychotic Drugs Based on EEG, Psychomotor Vigilance Task and Ratings Scales
DOI: 10.1016/s0924-9338(10)71119-6
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Summary
This study addresses the clinical challenge of persistent sedation, a common side effect of antipsychotic medications that significantly impacts patient quality of life, treatment adherence, metabolic health, and driving safety. The primary objective was to evaluate and compare the sedative effects of different antipsychotic drugs using three accessible methods suitable for routine psychiatric practice: electroencephalography (EEG), psychomotor vigilance testing, and subjective rating scales. The research involved 59 patients with schizophrenia (mean age 25.1 ± 3.6 years; 27 males, 22 females) who were undergoing monotherapy prior to discharge from an open psychiatric ward. The participants were categorized into three groups based on the sedative profile of their medication: a sedative group receiving olanzapine (n=33, mean dose 15.4 ± 5.9 mg), a moderate-sedative group receiving risperidone (n=12, mean dose 4.4 ± 1.8 mg), and a non-sedative group receiving aripiprazole or sertindole (n=14, mean doses 18.7 ± 6.2 mg and 15.5 ± 3.3 mg, respectively). Each patient underwent EEG recordings, completed a 28-minute Psychomotor Vigilance Task (Mackworth Clock Test), and filled out the Epworth Sleepiness Scale (ESS) along with sleep quality assessment scales. The results revealed distinct differences in physiological markers of sedation. Increased slow-wave EEG activity, indicative of sedation, was observed in 63.6% of patients treated with olanzapine and 66.7% of those treated with risperidone, compared to only 21.4% of patients on non-sedative antipsychotics (p< 0.05). However, these physiological differences did not translate significantly into performance metrics or subjective reports. Abnormal results on the psychomotor task were found in 30.3% of the olanzapine group, 41.7% of the risperidone group, and 28.6% of the non-sedative group, with no statistically significant differences between groups. Similarly, mean ESS scores were 6.9 ± 3.3 for olanzapine, 8.0 ± 3.0 for risperidone, and 5.4 ± 3.7 for the non-sedative group, also showing no significant variation. The study concludes that while EEG recordings effectively detect signs of sedation in patients treated with sedative antipsychotics, these physiological changes do not necessarily correspond to pronounced differences in psychomotor performance or subjective sleepiness ratings. This suggests that objective physiological measures like EEG may be more sensitive indicators of drug-induced sedation than behavioral tasks or self-reported scales in this clinical context.
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| Stage | Outcome | Tool | Model | Prompt | Attempts | Completed |
|---|---|---|---|---|---|---|
| discover | success | Crossref | — | — | 1 | 2026-08-09 |
| archive | success | canonical_url | — | — | 1 | 2026-08-09 |
| extract | success | pdftotext | — | — | 4 | 2026-08-10 |
| clean | success | clean | — | — | 2 | 2026-08-10 |
| chunk | success | chunk | — | — | 2 | 2026-08-10 |
| embed | success | embed | Qwen/Qwen3-Embedding-8B | — | 2 | 2026-08-10 |
| promote | success | — | — | — | 1 | 2026-08-09 |
| summarize | success | llm | qwen3.6-27b-nvidia | summ-v5 | 2 | 2026-08-10 |
| tag | success | vector_similarity | — | — | 17 | 2026-08-11 |
| verify | success | — | — | — | 2 | 2026-08-10 |
Summary generated by qwen3.6-27b-nvidia on 2026-08-10; verification: verified.
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